Locations Cassano's Hannibal 2860 James RoadHannibal, Missouri 63401(573) 221-5442Call Cassano's HannibalGet Directions Restaurant Hours Monday: 10am – 10pm Tuesday: 10am – 10pm Wednesday: 10am – 10pm Thursday: 10am – 10pm Friday: 10am – 11pm Saturday: 10am – 11pm Sunday: 10am – 10pm